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ADDERALL-XR (AMPHETAMINE, DEXTROAMPHETAMINE): INDICATIONS AND USAGE

Attention Deficit Hyperactivity Disorder

Adderall-XR (Amphetamine, Dextroamphetamine mixed salts) is indicated for the treatment of attention deficit hyperactivity disorder (ADHD).

The efficacy of Adderall-XR capsules in the treatment of ADHD was established on the basis of two controlled trials in children aged 6 to 12, one controlled trial in adolescents aged 13 to 17, and one controlled trial in adults who met DSM-IVR criteria for ADHD.

A diagnosis of ADHD (DSM-IVR) implies the presence of hyperactive-impulsive or inattentive symptoms that caused impairment and were present before age 7 years. The symptoms must cause clinically significant impairment, e.g., in social, academic, or occupational functioning, and be present in two or more settings, e.g., school (or work) and at home. The symptoms must not be better accounted for by another mental disorder. For the Inattentive Type, at least six of the following symptoms must have persisted for at least 6 months: lack of attention to details/careless mistakes; poor listener; lack of sustained attention; failure to follow through on tasks; avoids tasks requiring sustained mental effort; poor organization; loses things; easily distracted; forgetful. For the Hyperactive-Impulsive Type, at least six of the following symptoms must have persisted for at least 6 months: inappropriate running/climbing; fidgeting/squirming; leaving seat; difficulty with quiet activities; excessive talking; "on the go;" blurting answers; can't wait turn; intrusive. The Combined Type requires both inattentive and hyperactiveimpulsive criteria to be met.

Special Diagnostic Considerations

Specific etiology of this syndrome is unknown, and there is no single diagnostic test. Adequate diagnosis requires the use not only of medical but of special psychological, educational, and social resources. Learning may or may not be impaired. The diagnosis must be based upon a complete history and evaluation of the patient and not solely on the presence of the required number of DSM-IVR characteristics.

Need for Comprehensive Treatment Program

Adderall-XR (Amphetamines) is indicated as an integral part of a total treatment program for ADHD that may include other measures (psychological, educational, social) for patients with this syndrome. Drug treatment may not be indicated for all patients with this syndrome. Stimulants are not intended for use in the patient who exhibits symptoms secondary to environmental factors and/or other primary psychiatric disorders, including psychosis. Appropriate educational placement is essential and psychosocial intervention is often helpful. When remedial measures alone are insufficient, the decision to prescribe stimulant medication will depend upon the physician's assessment of the chronicity and severity of the child's symptoms.

Long-Term Use

The effectiveness of Adderall-XR (Amphetamine, Dextroamphetamine) for long-term use, i.e., for more than 3 weeks in children and 4 weeks in adolescents and adults, has not been systematically evaluated in controlled trials. Therefore, the physician who elects to use Amphetamines (Adderall-XR) for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient.



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  • Novo Healthcare and Pharma


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